t(11;22)(q24;q12) in giant cell tumour of bone

Bone: Giant cell tumour

The Giant-Cell Tumour of Bone

Amongst all the controversies regarding the classification of osteogenic neoplasms, the giantcell tumour, under one name or another, has always remained a distinct entity. In fact, the subject of contention in this connection has been the nomenclature of this distinct variety of tumour formation in the bone which, though locally destructive, practically never presents any of the general feature...

Multiple Giant-cell Tumour of Bone

The occurrence of more than one giant-cell tumour of bone in the same person (that is, the appearance of the tumour otherwise than as a solitary lesion) is so unusual that one accepts only with great hesitation an apparent instance of this; such a case must be carefully scrutinised to eliminate hyperparathyroidism. Jaffe (1958) observed a case ofgiant-cell tumour involving the lower end of an u...

Giant cell tumor of the sphenoid bone

Background: Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. Giant cell tumor (GCT) of the sphenoid bone is relatively rare. In this report, we describe a tumor of the greater wing of left sphenoid bone. Case presentation: A 31-year-old female was presented with headache, proptosis and diplopia of her left eye. Cranial magnetic resonance ima...

Giant Cell Tumor of Bone - an Overview

  Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal ...